Tuesday, December 29, 2009

Now Available in Aisle 3: H1N1 Vaccinations

After months of standing in line trying for adequate shipments of the H1N1 vaccine, pharmacies, supermarkets and other retailers with in-store clinics now are trying to make the most of an influx of supply now becoming more widely available.

“Right now there’s probably more supply than demand,” Troyen A. Brennan, chief medical officer at drugstore chain CVS Caremark, told the WSJ this morning. CVS is offering the swine-flu vaccinations in 23 states, while Rite-Aid has them in 30 states and Wal-Mart in 48 states. Walgreens, the No. 1 pharmacy chain by number of stores, will have them available in 49 states by year end, the WSJ says.

Of course, this ramp-up is happening while flu activity continues to decline in the U.S., according to the CDC. But the government push for people to still get H1N1 shots, especially now that there are enough supplies to give the vaccine to lower-risk groups.

For the retailers, vaccines may not be a huge profit center (most providers are charging $10 to $18 for a H1N1 shot), but they can build traffic. “We clearly see potential opportunity” in the vaccinations, spokesman Brian Dowling of supermarket operator Safeway told the WSJ. “The vast majority of our pharmacy customers shop the rest of the store.”

Booster Shot: WHO head Margaret Chan told a Geneva newspaper that “it is too soon to say that we have passed the peak of the [H1N1] flu pandemic on a worldwide scale….Winter is still long.” See more here.

Monday, December 28, 2009

Just How Big Is the Hole in the Medicare Doughnut?

Congress and the White House have set their sights on plugging the “doughnut hole,” the gap in Medicare drug coverage that can leave seniors liable for thousands of dollars a year in prescription costs. Bridging the gap might be easier if there were more data on how big the hole was and its closing costs down the road.

The Congressional Budget Office, the usual scorekeeper for tracking federal spending, hasn’t predicted how much it would cost to close the doughnut hole, a Washington Post article notes this morning. The paper says the only estimate of the cost of filling the gap comes from the Medicare program’s chief actuary, who put the figure at $31 billion over the next decade. There aren’t any budget forecasts going far enough into the future to predict what expanded drug benefit would cost the government once the gap is fully closed, the Post adds.

The House overhaul bill passed in November would gradually eliminate the doughnut hole over 10 years starting with adding $500 to cover drug costs covered by Medicare in 2010. The health overhaul passed by the Senate on Christmas Eve is missing that language, but Senate Leader Harry Reid said this month he wanted to adopt the House goal of closing the coverage gap in the final version of the legislation that Congress sends to President Obama for signing.

Drug makers said earlier this year they would offer a 50% discount on brand name drugs purchased by seniors in the doughnut hole. That’s part of the drug industry’s deal with Democrats to contribute $80 million over 10 years to the cost of the health overhaul. Here’smore on that.

Meanwhile, CBO did do a study in August on how plugging the doughnut hole would reduce what seniors’ total spending on prescription drugs but their Medicare premiums would increase. That study is detailed here.

Saturday, December 26, 2009

[MV] Happy Holidays from DDO Dance!

Hello there and thank you for your email. The LA Dance Department will be out of the office observing the holiday weekend from 12/23 and will return 12/28. If this is a casting emergency or of an urgent matter and you need to reach us right away, please call my cell at 323-304-5635. All others, your emails will be responded to when we return on Monday. Happy Holidays.

Jim Keith / DDO Dance
Director / Dance & Choreography Departments
Cell: 323-304-5635

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[MV] Happy Holidays from DDO Dance!

Hello there and thank you for your email. The LA Dance Department will be out of the office observing the holiday weekend from 12/23 and will return 12/28. If this is a casting emergency or of an urgent matter and you need to reach us right away, please call my cell at 323-304-5635. All others, your emails will be responded to when we return on Monday. Happy Holidays.

Jim Keith / DDO Dance
Director / Dance & Choreography Departments
Cell: 323-304-5635

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[MV] Happy Holidays from DDO Dance!

Hello there and thank you for your email. The LA Dance Department will be out of the office observing the holiday weekend from 12/23 and will return 12/28. If this is a casting emergency or of an urgent matter and you need to reach us right away, please call my cell at 323-304-5635. All others, your emails will be responded to when we return on Monday. Happy Holidays.

Jim Keith / DDO Dance
Director / Dance & Choreography Departments
Cell: 323-304-5635

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[MV] Happy Holidays from DDO Dance!

Hello there and thank you for your email. The LA Dance Department will be out of the office observing the holiday weekend from 12/23 and will return 12/28. If this is a casting emergency or of an urgent matter and you need to reach us right away, please call my cell at 323-304-5635. All others, your emails will be responded to when we return on Monday. Happy Holidays.

Jim Keith / DDO Dance
Director / Dance & Choreography Departments
Cell: 323-304-5635

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[MV] Yahoo! Auto Response

Happy Holidays! 11-16 Entertainment will be closed for the holiday through Monday January 4th, 2010. We will be checking email periodically for urgent matters. Thank you!
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[MV] Réponse en cas d'absence

Hello=2C
=A0=A0=A0 hows everything going? one of my friends has a site m= ainly for
electronics=2Cand price is fanscinating! laptop=2CIphone and moto= rcycles
are most popular stuff=2Ctheir items are fully with original qualit=
y=2Cfurthermore=2Cif you wanna do wholesale busines=2Cplease do not hesitat=
e to contact them.
Mail: xinkeke2= 009@188.com[1]
MSN : xi= nkekeshopping2@hotmail.com[2]
web: www.xinkeke.com[3]
Online Customer service hours:8:00P= M - 6:00AM=A0 =2C7 days a
week=2CBeijing=2CChina(Timezone: UTC+8hours)
please forgive me for this email if you are not interested in anything upon=
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[MV] Happy Holidays from DDO Dance!

Hello there and thank you for your email. The LA Dance Department will be out of the office observing the holiday weekend from 12/23 and will return 12/28. If this is a casting emergency or of an urgent matter and you need to reach us right away, please call my cell at 323-304-5635. All others, your emails will be responded to when we return on Monday. Happy Holidays.

Jim Keith / DDO Dance
Director / Dance & Choreography Departments
Cell: 323-304-5635

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[MV] Happy Holidays from DDO Dance!

Hello there and thank you for your email. The LA Dance Department will be out of the office observing the holiday weekend from 12/23 and will return 12/28. If this is a casting emergency or of an urgent matter and you need to reach us right away, please call my cell at 323-304-5635. All others, your emails will be responded to when we return on Monday. Happy Holidays.

Jim Keith / DDO Dance
Director / Dance & Choreography Departments
Cell: 323-304-5635

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[MV] Réponse en cas d'absence

Hello=2C
=A0=A0=A0 hows everything going? one of my friends has a site m= ainly for
electronics=2Cand price is fanscinating! laptop=2CIphone and moto= rcycles
are most popular stuff=2Ctheir items are fully with original qualit=
y=2Cfurthermore=2Cif you wanna do wholesale busines=2Cplease do not hesitat=
e to contact them.
Mail: xinkeke2= 009@188.com[1]
MSN : xi= nkekeshopping2@hotmail.com[2]
web: www.xinkeke.com[3]
Online Customer service hours:8:00P= M - 6:00AM=A0 =2C7 days a
week=2CBeijing=2CChina(Timezone: UTC+8hours)
please forgive me for this email if you are not interested in anything upon=
them.
=
--- Links ---
1 3D"mailto:xinkeke2009@188.com"
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[MV] Réponse en cas d'absence

Hello=2C
=A0=A0=A0 hows everything going? one of my friends has a site m= ainly for
electronics=2Cand price is fanscinating! laptop=2CIphone and moto= rcycles
are most popular stuff=2Ctheir items are fully with original qualit=
y=2Cfurthermore=2Cif you wanna do wholesale busines=2Cplease do not hesitat=
e to contact them.
Mail: xinkeke2= 009@188.com[1]
MSN : xi= nkekeshopping2@hotmail.com[2]
web: www.xinkeke.com[3]
Online Customer service hours:8:00P= M - 6:00AM=A0 =2C7 days a
week=2CBeijing=2CChina(Timezone: UTC+8hours)
please forgive me for this email if you are not interested in anything upon=
them.
=
--- Links ---
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[MV] Réponse en cas d'absence

Hello=2C
=A0=A0=A0 hows everything going? one of my friends has a site m= ainly for
electronics=2Cand price is fanscinating! laptop=2CIphone and moto= rcycles
are most popular stuff=2Ctheir items are fully with original qualit=
y=2Cfurthermore=2Cif you wanna do wholesale busines=2Cplease do not hesitat=
e to contact them.
Mail: xinkeke2= 009@188.com[1]
MSN : xi= nkekeshopping2@hotmail.com[2]
web: www.xinkeke.com[3]
Online Customer service hours:8:00P= M - 6:00AM=A0 =2C7 days a
week=2CBeijing=2CChina(Timezone: UTC+8hours)
please forgive me for this email if you are not interested in anything upon=
them.
=
--- Links ---
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[MV] Antville Music Video Awards 2009: WINNERS

The hive-minded collective of videos.antville.org has just announced the
winners of the Antville Music Video Awards 2009.
And the winners are:

most fun video
*Metronomy "A Thing For Me" Dir: Megaforce*
http://videos.antville.org/stories/1863449/

best animated video
*Coldplay "Strawberry Swing" Dir: Shynola*
http://videos.antville.org/stories/1918313/

best performance video
*Grizzly Bear "Two Weeks" Dir: Patrick Daughters*
http://videos.antville.org/stories/1905199/

best narrative video
*Depeche Mode "Wrong" Dir. Patrick Daughters*
http://videos.antville.org/stories/1882317/

Hype Williams Award (for best mainstream rap video)
*Kanye West "Welcome To Heartbreak" Dir: Nabil*
http://videos.antville.org/stories/1880850/

best choreography
*Lady Gaga "Bad Romance" Dir: Francis Lawrence, Choreographer: Laurie
Ann Gibson*
http://videos.antville.org/stories/1945587/

best art direction
*Charlotte Gainsbourg & Beck "Heaven Can Wait" Dir. Keith Schofield, PD:
Megan Fenton & Philip Godwin*
http://videos.antville.org/stories/1948117/

best editing
*Röyksopp "This Must Be It" Dir. & Editor: Andreas Nilsson & Flip Nilsson*
http://videos.antville.org/stories/1934778/

best cinematography
*Depeche Mode - "Wrong" Dir: Patrick Daughters, DP: Shawn Kim*
http://videos.antville.org/stories/1882317/

best unknown/unsigned director
*Kevin Phillips*
http://videoville.org/wiki/Kevin_Phillips

best new director
*Danakil*
http://videoville.org/wiki/Danakil

director of the year
*Megaforce*
http://videoville.org/wiki/Megaforce

best music video of the year
*Charlotte Gainsbourg & Beck "Heaven Can Wait" Dir: Keith Schofield*
http://videos.antville.org/stories/1948117/


More information:
http://videos.antville.org/stories/1958007/

Past awards cycles:
http://www.videoville.org/wiki/Antville_Digests#Antville_Music_Video_Awards

Videos.antville.org is a 7-year old hive-minded website of music video
aficionados - including directors, editors, DPs, commissioners,
executive producers, and others who work in the music video industry -
who gather together to discuss and critique each others' work.

The Antville Music Video Awards is in its fifth year of celebrating the
best in the world of music video.

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Monday, November 30, 2009

What the Senate Bill Means for Your Health-Insurance Premiums

The CBO is out this afternoon with its latest round of estimates — this time, on what the Senate health-care bill would mean for health-insurance premiums. The short answer: Not much, for most working people.

The long answer is more complicated, so we’ll break it down into the three categories the CBO uses. The estimates compare premiums in 2016 under the Senate bill versus premiums in 2016 under current law.

Premiums for people who get health insurance through a large group (including companies with more than 50 people) would be unchanged, or maybe a little lower, under the Senate bill. People in this category account for 70% of the nonelderly population CBO looked at.

Premiums for people who get insurance through a small group would also be largely unchanged. But a small percentage of people who get insurance through a small group would be eligible for insurance subsidies, and those people would see their rates fall by about 10%.

Premiums for people who buy health insurance on the individual market would go up by 10% or more. But the majority of people in this category would be eligible for subsidies, and those people would wind up paying nearly 60% less, on average, under the Senate bill, because of the effect of the subsidies.

For more details on these numbers, see the table on page 5 of the CBO’s estimate. The subsidies are based on income, and explained in detail in Table 2 on the last page of the estimate.

As always, these sorts of estimates — both for what premiums would be under current law, and for what they’d be under the senate health bill — are subject to plenty of uncertainty, so take them with a grain of salt. But you already knew that.

Thursday, November 5, 2009

Kellogg: Rice Krispies Won’t Protect Your Kid From Swine Flu

Kellogg said it’s removing the great big banner on the front of Rice Krispies boxes that says the cereal “helps support your child’s immunity.”

The move seems a bit odd, that it was only July when the company rolled out the new claim, which went along with a new formulation of the cereal that included higher amounts of vitamins A, B, C and E. In a brief statement announcing the end of the immunity banner, Kellogg said:

While science shows that these antioxidants help support the immune system, given the public attention on H1N1, the Company decided to make this change.

The statement doesn’t mention that, just last week, the San Francisco city attorney wrote the company a letter asking for a substantiation of the immunity claim (and also citing the H1N1 flu pandemic). The letter said, in part:

I am concerned that the prominent use of the Immunity Claims to advertise a sugar-laden, chocolate cereal like Cocoa Krispies may mislead and deceive parents of young children. … At a time when parents are increasingly worried about the spread of the H1N1 virus (”swine flu”), it is vitally important that parents receive accurate information about what they can do to protect their children’s health.

There’s a broader story at work here: Tension between food companies putting more health claims on the front of their packages, and governments looking to validate those claims. Several big food companies recently suspended their “Smart Choice” labeling program, after the FDA said it was working on new rules for front-of-package labeling. And the EU’s food agency recently released opinions on hundreds of health claims made by food manufacturers.

Wednesday, October 21, 2009

The Problem With Ranking Countries’ Health-Care Systems

The oft-cited WHO ranking that said the U.S. has the 37th best health-care system in the world is dated and had problems even when it was new, WSJ stats maven Carl Bialik writesin his column today.

The ranking was published in 2000, and came up against a major problem: Good data weren’t available from many countries. So researchers used other measures, such as literacy rates and income inequality, to infer health data. The report’s editor in chief later called the findings “spurious” noting the lack of solid data.

Still, it’s worth noting that the U.S. doesn’t fare particularly well on some measures where there are good data — we’re 24th in the world in male life expectancy and 35th in the world in female life expectancy, Bialik notes.

At the same time, life expectancy is a product of many factors — not only the quality of a nation’s medical care, but also issues such as nutrition, smoking rates and the like.

Friday, October 16, 2009

When the Law Allows Hospital Errors to Remain Secret

Connecticut law requires hospitals to tell the state Department of Public Health when certain medical errors harm patients. But some tweaks that were made to the law five years ago mean that hospitals report far fewer incidents, and those incidents that are reported are often kept secret from the public, the Hartford Courant reports.

Connecticut adopted “adverse event” legislation in 2002, a few years after the Institute of Medicine published its influential “To Err is Human” report that said as many as 98,000 people die every year in U.S. hospitals due to human error.

But Connecticut hospitals complained about the reports that were starting to be made public, the Courant says. In 2004, revisions to the law limited the types of events that need to be reported and said the data filed by the hospitals would stay secret unless they prompted an investigation.

Since the redrafting, the paper says, public access to hospitals’ adverse events reports has fallen 90%. In each of the last five years, between 228 and 247 reports have been made under the new law, resulting in about 60 investigations each year.

“The details of more than a dozen sexual assaults are concealed in the health department’s files, along with at least 30 cases in which sponges or other objects were left in patients’ bodies after surgery,” the paper said based on its analysis.

Hospital spokespeople quoted in the article say their institutions understand and follow the law’s provisions . One said “questionable cases” were reviewed by her hospital’s senior management and sent on to the state if they meet the reporting criteria.

Monday, October 12, 2009

[MV] Réponse en cas d'absence

Hello=2C
=A0=A0=A0 hows everything going? one of my friends has a site m= ainly for
electronics=2Cand price is fanscinating! laptop=2CIphone and moto= rcycles
are most popular stuff=2Ctheir items are fully with original qualit=
y=2Cfurthermore=2Cif you wanna do wholesale busines=2Cplease do not hesitat=
e to contact them.
Mail: xinkeke2= 009@188.com[1]
MSN : xi= nkekeshopping2@hotmail.com[2]
web: www.xinkeke.com[3]
Online Customer service hours:8:00P= M - 6:00AM=A0 =2C7 days a
week=2CBeijing=2CChina(Timezone: UTC+8hours)
please forgive me for this email if you are not interested in anything upon=
them.
=
--- Links ---
1 3D"mailto:xinkeke2009@188.com"
2 3D"mailto:xinkekeshopping2@hotmail.com"
3 3D"http://www.xinkeke.com"
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[MV] Réponse en cas d'absence

Hello=2C
=A0=A0=A0 hows everything going? one of my friends has a site m= ainly for
electronics=2Cand price is fanscinating! laptop=2CIphone and moto= rcycles
are most popular stuff=2Ctheir items are fully with original qualit=
y=2Cfurthermore=2Cif you wanna do wholesale busines=2Cplease do not hesitat=
e to contact them.
Mail: xinkeke2= 009@188.com[1]
MSN : xi= nkekeshopping2@hotmail.com[2]
web: www.xinkeke.com[3]
Online Customer service hours:8:00P= M - 6:00AM=A0 =2C7 days a
week=2CBeijing=2CChina(Timezone: UTC+8hours)
please forgive me for this email if you are not interested in anything upon=
them.
=
--- Links ---
1 3D"mailto:xinkeke2009@188.com"
2 3D"mailto:xinkekeshopping2@hotmail.com"
3 3D"http://www.xinkeke.com"
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Sunday, October 11, 2009

[MV] I can't think of the title to this song.

I can see the music video, but I can't remember the artist, lyrics, or
title. The video mainly focuses on a skinny white guy who sings to the
camera. The video appears to be in a house or apartment. The music is
sort of creepy. In the background of the singer, these ink blotch-like
figures start to appear. These black splotches move around and kind of look
like they're living. I think the song lyrics are basically about a
depressed guy whos trying to get back with his girlfriend, but I might be
wrong about that. I know this is a really bad description but maybe someone
will know what song I'm talking about.
--
"And you don't eat crackers in the bed of your future. Cause you get all
scratchy!" - The Tick


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Monday, September 28, 2009

Afraid of Germs? Don’t Even Think About Becoming a Teacher

With the spread of swine flu and mounting concern over drug-resistant superbugs like MRSA, it’s no wonder we are a nation of germophobes, as I write in my latest WSJ Informed Patient column. The CDC warns that in addition to spreading from person to person by coughing and sneezing, the flu virus can be transmitted by touching a surface or object that has flu virus on it and then touching their mouth or nose.

Reliable data on the direct link between contact with germy surfaces and the development of disease are scant — in other words, we don’t know if touching that airplane bathroom handle was the reason we got sick a few days later. But if we want to know where the microbes are most likely to be lurking -– and which occupations are more likely to be exposed — researchers at the University of Arizona’s Department of Soil, Water and Environmental Sciences have been diligently swabbing offices, homes and public spaces over the last few years to find out.

Studies conducted in 2006 and 2009 showed that women’s offices are dirtier than men’s (see here and here) but that MRSA was isolated twice as often in men’s than women’s offices. The germiest jobs? Not surprisingly, school teachers, from close contact with children who each year pass around billions of germs that cause colds, flu and digestive problems, head the list. Surfaces regularly used by teachers had 10 times more bacteria per square inch when compared with other professions.

Accountants and bankers were high on the germy scale, while lawyers were found to have the least amount of bacteria per square inch. Accountants had the germiest doorknobs and pens, while teachers had the germiest computer keyboards.

The University of Arizona studies have earned microbiologist Charles Gerba, who heads the research, the nickname “Dr. Germ.” Much of his funding comes from consumer-products companies such as Clorox and Procter & Gamble, which market cleaners and disinfectants, but he says he also has grants from the federal government.

Dr. Gerba tells the Health Blog that the amount of bacteria or germs found on each surface is thought to be directly related to cleaning practices, and corporate sponsors hope to use the studies to identify the benefits of disinfection and develop more targeted cleaning products. In one of his studies on germs in the office, people who said they use disinfectants have less than a quarter of the bacteria than those that said they don’t.

A co-worker infected with salmonella, which causes fever, abdominal cramps and diarrhea, can leave traces of stool on his or her hands after using the bathroom, then transmit them to communal surfaces like microwave oven keypads, telephone receivers and pens. Bacteria can last on surfaces for several hours, so the next person to touch the same surface is at risk of picking up the germs and ingesting them with an errant finger in the mouth. While our immune systems protect us from most germs we might encounter in the office, it’s better to be safe than sorry.

Like most hygiene experts, Dr. Gerba recommends regular hand washing with soap or an alcohol-based hand sanitizer after shaking hands, and after contact with surfaces routinely touched by others. In fact, it’s generally a good idea to wash up after coming inside from any public place.

If you are especially paranoid, avoid certain places where germs are likely to be in high concentrations. “I stay out of day-care centers,” says Dr. Gerba.

Wednesday, August 26, 2009

Millions Exposed to High Radiation from Medical Tests

Here’s the latest reason to wonder whether you really need that CT scan the doctor’s ordering “just to be sure”:

In any given year, roughly four million Americans between the ages of 18 and 64 are exposed to “high” or “very high” doses of radiation as a result of medical testing, according to a studypublished today in the New England Journal of Medicine.

Estimating the risk of cancer from a given dose of radiation is notoriously difficult, and the authors of the study don’t quantify a specific cancer risk from a given dose of radiation. But the paper does note that the per capita dose of radiation Americans are exposed to because of medical testing has increased sixfold since the 1980s.

The study, which included funding from the NIH, looked at data on nearly one million people from 2005 to 2007.

While many medical tests are clearly necessary — and the benefits of the test outweigh the risk of the radiation — in other cases it’s less clear. A perspective piece that accompanies the study calls for a much more cautious approach, with more study of the benefits of imaging tests before they are put into widespread use.

“We have to think and talk explicitly about the elements of danger in exposing our patients to radiation,” writes the piece’s author, an NIH doc named Michael Lauer. What’s more, he argues, doctors should weigh a patient’s previous history of high-radiation tests and explain the possibility year after year of high-radiation testing could lead to cancer.

Thursday, July 9, 2009

Swine Flu Update: Vaccine for Kids, Tamiflu Resistance

A few notable developments in the swine flu (aka H1N1 flu) pandemic:

The U.S. is planning a vaccination campaign that could start in October, with school-age children among the first to be offered a shot, Dow Jones Newswires reports. The new vaccine still has to be developed and tested. But if it works, the government will purchase much of the vaccine. Unlike seasonal flu, which disproportionately affects the elderly, the swine flu has hit particularly hard among school children.

Officials have documented three cases of Tamiflu-resistant swine flu, but they appear to be isolated cases and not evidence of widespread resistance, the WHO said. In one case, testing revealed that a teenage girl who flew from San Francisco to Hong Kong was infected with a Tamiflu-reistant strain, despite the fact that she hadn’t been treated with Tamiflu — suggesting a resistant strain that has the ability to spread from person to person, the New York Times reports. There is no evidence that the resistant strain is widespread, and Tamiflu-resistant flu is susceptible to Relenza, another drug.

The French government is planning to spend nearly $1 billion to buy 100 million doses of vaccine from Sanofi-Aventis, GlaxoSmithKline, Novartis and Baxter, reports the French newspaper Le Parisien. (The U.S. has already appropriated $1 billion for vaccine ingredients and up to $7.5 billion more for rolling out the vaccine if initial testing goes well, the NYT notes.)

Monday, June 22, 2009

AARP Wins One With Pharma Pledge on Medicare Doughnut Hole

The pharmaceutical industry’s promise to offer Medicare beneficiaries trapped in a coverage gap a 50% discounts on expensive drugs is a lobbying victory for another major player in health care: the seniors group AARP.

The AARP has pushed to eliminate the gap, known as the doughnut hole, since Congress added the drug benefit to Medicare through a controversial 2003 law. But the talk with the drug industry went nowhere, mainly because the industry focused on low-income seniors but the AARP wanted relief for all beneficiaries, said John Rother, AARP’s executive vice president for policy.

That changed after drug makers pledged last month to reduce health spending as part of a health-care overhaul. Industry officials held meetings with the Senate Finance Chairman Max Baucus and White House officials.

The deal was sealed when Billy Tauzin, head of the drug-industry group PhRMA, called Baucus at 6 p.m. Friday. President Obama formally announced the agreement today with the drug industry pledging to spend $80 billion to reduce drug costs. (Our earlier post is here.)

This year, the doughnut hole begins after seniors and their drug plans have spent $2,700. Beneficiaries then must bear all costs until their out-of-pocket expenses reach $4,350 when Medicare again covers most drug costs for the rest of the year.

Today’s agreement applies to brand-name drugs and biologics, expensive drugs that can get seniors into the doughnut hole more quickly than generics. It would only become effective if Congress passes legislation to overhaul health care.

AARP’s Rother said the group still wants to “close the doughnut hole entirely.” See AARP’s statement here).

Friday, May 22, 2009

Scientists Find ‘Happyhour’ Gene

As the long weekend fast approaches, we’d be remiss if we didn’t tell you about a gene called “happyhour.”

The folks in the Heberlein lab at the University of California, San Francisco, gave it that name because they found that fruit flies with a mutation of the gene were relatively resistant to the intoxicating effects of alcohol.

Why is this finding important? Generally, the more alcohol it takes to get you drunk, the more likely you are to become an alcoholic, Ulrike Heberlein, the study’s lead author, tells the Health Blog. So reducing your body’s resistance to alcohol’s effects might be one way to fight alcoholism. To put it another way: It’s good to be a cheap date. Here’s the study, published in the journal Cell.

The normal version of “happyhour,” it turns out, inhibits the effects of a protein called epidermal growth factor, or EGF. The mutant version of the gene doesn’t do that.

There are a bunch of cancer drugs that inhibit the cellular proteins stimulated by EGF. The researchers gave one of the drugs, Tarceva, to rats that were already used to consuming large amounts of alcohol. They then presented the rats with both alcohol and water, and let the animals make the choice. The rats reduced their alcohol consumption, favoring water, Heberlein tells us.

Heberlein says she’d like to find out whether Tarceva has the same effect in humans. She notes that it took relatively low doses of Tarceva in rats to have that effect, so there’s some hope that it would also be possible to use a low dose of the drug in people. That’s important, since it could be a problem to give high doses of powerful cancer drugs to patients who don’t have cancer.

In any event, happyhour is one out of many genes, plus environmental factors, that likely contribute to alcoholism. The “ultimate drug” to fight alcoholism might be a cocktail that targets a bunch of things at once, Heberlein said.

The study was funded by the National Institute on Alcohol Abuse and Alcoholism, the Department of Defense and the state of California. Genentech and OSI Pharmaceuticals donated the Tarceva, Heberlein said.

Wednesday, April 29, 2009

Considering the Range of Pandemics

“The biggest question right now is this: How severe will the pandemic be?”

That’s how the head of the WHO boiled it down today as the WHO raised the pandemic-alert level to Phase 5, signaling that a pandemic is imminent.

Officially, Phase 5 means that more than one country in a single WHO region has sustained, human-to-human transmission of a new disease. The spread of swine flu in the U.S. and Mexico meets that definition. If sustained human-to-human transmission is demonstrated elsewhere in the world, we can expect the WHO to move to Phase 6, signaling a full-blown pandemic. See more about the different phases here.

There are relatively mild pandemics, in which many people come down with a case of the flu, but the vast majority recover without needing to be hospitalized. More severe pandemics are associated with higher rates of hospitalization and death.

As Chan’s question indicates, we’re still too early in this outbreak to know how mild or severe it will be.

Friday, March 27, 2009

What the Republicans’ Budget Outline Says On Health Reform

Republican lawmakers put out a proposal yesterday to counter many of the ideas in the Obama administration budget now working its way through Congress. As the WSJ’s Political Wisdom notes, the Republican proposal — online here — doesn’t include any hard numbers or deficit projections.

GOP leaders say the details are coming next week. In the meantime, here’s what yesterday’s report has to say about health reform, one of the main themes of the Obama budget.

The report attacks a proposed government-run health plan that would compete with private insurers, arguing that “employers would save billions of dollars by ending their current coverage and dumping their employees into the government-run plan.” The government plan would “quickly become a de facto single-payer system,” the Republicans argue. We wrote earlier this week about the debate over a government-run plan.

The Republicans call for raising premiums wealthy seniors pay for drug coverage under Medicare part D, singling out a few famous billionaires to bolster their argument: “[W]ealthy seniors like Warren Buffett and George Soros can afford to pay $2 per day more … .”

Echoing ideas we heard from Republican presidential candidates, the report calls for changing the tax code to encourage individuals and small business to buy insurance, and allowing insurers to sell policies across state lines. The Republicans also call for tort reform to “end the unnecessary defensive medicine practices increasing costs for all Americans,” another longtime GOP favorite.

Wednesday, February 11, 2009

Mead Johnson Has Right Market Formula

Some positive stock-market news on the health front today: Trading began in the stock of infant-formula maker Mead Johnson after its $720 million partial initial public offering.

Though there hasn’t been a successful IPO in months, investors appeared optimistic about Mead Johnson. Last night the company increased the size of its offering to 30 million shares at $24, at the top end of the estimated price range, due to “overwhelming demand for the stock,” Mead Johnson CEO Steve Golsby told the Health Blog.

The company had been planning to offer 25 million shares in the range of $21 to $24. Trading opened at $26 and the stock rose to $26.43, up 1.65%, in 4 p.m. composite trading on the New York Stock Exchange.

The company expects to grow globally in 2009, particularly in Asian and Latin American markets where birth rates are increasing, and by designing formulas that will improve infant allergies, immune systems and brain growth. Golsby said he didn’t see Mead Johnson expanding to target the adult population, but instead would remain “solely” a pediatric nutrition company.

Though Mead Johnson’s Enfamil brand is priced at a premium, the company said it hasn’t seen any softness in sales due to the economic downturn and doesn’t expect to. “Parents will not compromise on the nutrition they provide their kids,” Golsby said.

“We are clearly a premium priced pediatric nutritional company. We have to offer value,” he said. “We’re confident we will do that.”

Parent Bristol-Myers Squibb retains an 85% stake in the company, but “with its own publicly traded equity, Mead Johnson will be better able to accelerate its growth,” Bristol-Myers CEO James Cornelius said in a statement.